Mitochondrial DNA synthesis fuels NLRP3 inflammasome.

Rebecca C Coll,Caroline L Holley,Kate Schroder

CELL RESEARCH（2018）

引用 19|浏览5

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摘要

Mitochondria-derived signals are associated with NLRP3 inflammasome activation. A recent study in Nature by Zhong et al. shows that inflammasome priming drives new mitochondrial DNA synthesis, and proposes this to be a prerequisite for NLRP3 inflammasome signaling.

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关键词

NLRP3 Inflammasome,NLRP3 Activation,mtDNA Synthesis,Transcription Factor A, Mitochondrial (TFAM),mtDNA Release

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