Salidroside attenuates interleukin-1β-induced inflammation in human osteoarthritis chondrocytes.

Salidroside, a bioactive constituent isolated from Rhodiola rosea, has been reported to have anti-inflammatory effects. However, the effects of salidroside on interleukin (IL)-1-stimulated osteoarthritis (OA) chondrocytes remain to be elucidated. Thus, this study aimed to evaluate the anti-inflammatory effects of salidroside on IL-1-stimulated human OA chondrocytes and explore its underlying mechanisms. Our results showed that salidroside significantly inhibited the production of nitric oxide and prostaglandin E-2, as well as suppressed the expression of inducible nitric oxide synthase and cyclooxygenase-2 in IL-1-stimulated chondrocytes (P<.05). In addition, salidroside also suppressed IL-1-induced matrix metalloproteinases production in human OA chondrocytes (P<.05). Furthermore, pretreatment with salidroside prevented IL-1-induced NF-B activation in OA chondrocytes (P<.05). In conclusion, the current study demonstrated that salidroside inhibited the IL-1-induced inflammatory response in OA chondrocytes via inhibition of NF-B activation.