The G-protein biased mu-opioid agonist, TRV130, produces reinforcing and antinociceptive effects that are comparable to oxycodone in rats.

C Austin Zamarripa,Shelley R Edwards,Hina N Qureshi, John N Yi,Bruce E Blough,Kevin B Freeman

Drug and Alcohol Dependence（2018）

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摘要

•TRV130 was compared to oxycodone in self-administration and thermal antinociception.•TRV130 produced reinforcing effects that were equipotent to oxycodone.•TRV130 produced thermal antinociceptive effects that were equipotent to oxycodone.

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关键词

Biased agonists,TRV130,Oxycodone,Self-administration,Opioid

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