Screening of TNF-α gene polymorphisms in patients with extremity chronic osteomyelitis in China.

Aim: This study aims to investigate the link between TNF- gene SNPs and patients with extremity chronic osteomyelitis in China. Methodology: Our study included 433 subjects, composed of 233 extremity chronic osteomyelitis patients and 200 controls. Six single-nucleotide polymorphisms (rs1799964, rs1800630, rs1799724, rs1800750, rs1800629 and rs361525) in TNF- gene were detected by the SNaPshot genotyping method. Results: Significant genotype distribution of rs1799964 was identified between patients and healthy controls (p=0.045). In addition, statistical difference was found between rs1799964 SNP and the susceptibility to extremity chronic osteomyelitis (p=0.044). Conclusion: We reported for the first time that TNF- gene SNP rs1799964 contributes to the elevated venture of extremity chronic osteomyelitis in China.