Identification of new pyrrolo[2,3-d]pyrimidines as potent VEGFR-2 tyrosine kinase inhibitors: Design, synthesis, biological evaluation and molecular modeling.

•Target compounds were designed based on literature survey and bioisosteric modification of VEGFR-2 inhibitors.•Thirty two novel pyrrolo[2,3-d]pyrimidine derivatives were synthesized and biologically evaluated.•Docking study using CDOCKER protocol in Accelrys Discovery Studio® 2.5 software was performed to interpret the biological evaluation results on the basis of the ligand-protein interactions.•Field alignment technique provided by Cresset's FieldAlign® module, was also applied for more interpretation and understanding of the biological data.