DESIGN OF A SELECTIVE RCEYM-REDUCTION FOR THE GENERATION OF DIFFERENT SYNTHETIC SCAFFOLDS.

A tandem process of ring-closing enyne metathesis (RCEYM)-reduction using modern ruthenium catalysts and a hydrogen donor is described. This straightforward methodology is useful for C(sp(3)) generation under mild reaction conditions. Variables such as solvent, catalyst, hydride source, and temperature were adjusted toward the exclusive formation of different products.