Direct Synthesis of Α-Iodoenones by IPy2BF4-Promoted Rearrangement of Propargylic Esters
Journal of organic chemistry(2018)
Abstract
A direct access to α-iodoeones from iodonium ion and propargylic tosylates or acetates is described. Bis(pyridine) iodonium tetrafluoroborate (IPy2BF4, Barluenga's reagent) promotes the rearrangement of these propargylic alcohol derivatives in mild conditions. The transformation gives β-unsubstituted, β-monosubstituted, and β,β-disubstituted α-iodoenones in high yields. β-Substituted α-iodoenones are obtained with excellent ( Z)-selectivity.
MoreTranslated text
AI Read Science
Must-Reading Tree
Example
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined