Resveratrol and dimethyl fumarate ameliorate depression-like behaviour in a rat model of chronic unpredictable mild stress.

•CUMS can be a realistic analogue of the strains of everyday life.•Resveratrol and dimethyl fumarate relieved CUMS-induced depressive-like behaviors.•They modulated oxidative stress, inflammation and apoptosis.•They boosted hippocampal BDNF and β-catenin levels expression levels.•Levels of serum and hippocampal serotonin are correlated.