Loss of transforming growth factor-β1 in epithelium cells affects enamel formation in mice.
Archives of Oral Biology（2018）
Abstract
•Use the TGF-β1 conditional knockout method to research.•Amelx, Ambn, Enam were increased in enamel organs of cKO mice.•Amtn, Klk4, C4orf26 and Wdr72 were decreased in enamel organs of cKO mice.•The enamel of TGF-β1 cKO mice displayed severe attrition and lower density.
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Key words
Transforming growth factor-beta1,Conditional knockout,Enamel mineralization,Ameloblasts,Enamel matrix protein
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