Multispectral Optoacoustic Tomography in Assessment of Breast Tumor Margins During Breast-Conserving Surgery: A First-in-human Case Study.

Multispectral optoacoustic tomography (MSOT) is an innovative state-of-the-art imaging modality that has gained popularity for in vivo breast imaging in recent years. Combining high-resolution images with endogenous differentiation of biochemical contents, MSOT could be an accurate ex vivo imaging modality for assessment of tumor margins during breast-conserving surgery to reduce margin positivity rates. Accurate intraoperative assessment of margins could lead to more precise surgery, allowing a smaller volume of breast tissue to be removed without compromising the resection margins. To the authors' knowledge, there has been no ex vivo study conducted to this day that uses MSOT in the assessment of breast tumor margins after lumpectomy. Hence, we would like to present the first case of breast tumor margin assessment using MSOT in a 55-year-old patient who underwent breast-conserving surgery for invasive ductal carcinoma. (C) 2018 The Authors. Published by Elsevier Inc.