Antineoplastic effect of pectic polysaccharides from green sweet pepper (Capsicum annuum) on mammary tumor cells in vivo and in vitro.

Eliana Rezende Adami,Claudia Rita Corso,Natalia Mulinari Turin-Oliveira,Claudia Martins Galindo,Letícia Milani,Maria Caroline Stipp,Georgia Erdmann do Nascimento,Andressa Chequin,Luisa Mota da Silva,Sérgio Faloni de Andrade,Rosangela Locatelli Dittrich,José Ederaldo Queiroz-Telles,Giseli Klassen,Edneia A S Ramos,Lucimara M C Cordeiro,Alexandra Acco

Carbohydrate Polymers（2018）

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摘要

•The polysaccharides from green sweet pepper (CAP) presented antineoplastic effects against mammary tumor lineages.•CAP treatment reduced the gene expression of VEGF in tumor cells in vivo and in vitro.•CAP treatment reduced the area of vessels in Ehrlich tumor.•CAP treatment induced necrosis in Ehrlich solid tumors.•CAP treatment increased the levels of IL-6 in Ehrlich tumors in mice.

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关键词

Ehrlich solid tumor,Pectic polysaccharide,Green sweet pepper,VEGF,Mammary tumor cells,Interleukin-6

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