A MAPK/c-Jun-mediated switch regulates the initial adaptive and cell death responses to mitochondrial damage in a neuronal cell model.

Thomas A Ryan, Katherine M Roper,Jacquelyn Bond,Sandra M Bell,Sean T Sweeney,Ewan E Morrison

The international journal of biochemistry & cell biology（2018）

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摘要

•Undifferentiated/differentiated SH-SY5Y cells provide distinct model systems.•Parkin specifically sensitises to mitochondrial uncoupling.•Kinases differentially regulate c-Jun activity depending on stress levels.•Parkin exists in a feedback loop with c-Jun and its upstream kinases.

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关键词

AP-1,ASK1,BDNF,ERK,IEG,JNK,MAPK,MOM,PD,RA,ROS,SNpc,TRE,UPS

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