SCC4 cell monolayers as an alternative sublingual barrier model: influence of nanoencapsulation on carvedilol transport.

Paula Dos Santos Chaves,Fernanda Visioli,Andréia Buffon,Adriana Raffin Pohlmann,Sílvia Stanisçuaski Guterres,Ruy Carlos Ruver Beck

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY（2019）

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摘要

Objective: To evaluate, for the first time, the use of SCC4 cell monolayers as an alternative sublingual barrier model and study the influence of nanoencapsulation on carvedilol transport across SCC4 cell monolayers.

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关键词

Carvedilol,Eudragit((R))RS100,nanocapsules,SCC4 cells,transport studies

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