Early nurture epigenetically tunes the oxytocin receptor.

Allison M Perkeybile,C Sue Carter,Kelly L Wroblewski,Meghan H Puglia,William M Kenkel,Travis S Lillard,Themistoclis Karaoli,Simon G Gregory, Niaz Mohammadi, Larissa Epstein,Karen L Bales,Jessica J Connelly

Psychoneuroendocrinology（2019）

引用 83|浏览31

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摘要

•4 CpG sites in the Oxtr promoter region are homologous in humans and prairie voles.•Low levels of early parenting lead to high Oxtr DNA methylation in brain and blood.•High Oxtr methylation is associated with low Oxtr gene expression.•Low levels of early care lead to low OXTR density, likely via high Oxtr methylation.•Peripheral measures of Oxtr DNA methylation predict central levels.

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关键词

OXTR,DNA methylation,Oxytocin,Social behavior,Prairie vole

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