Possible therapeutic potential of berberine in the treatment of STZ plus HFD-induced diabetic osteoporosis.
Biomedicine & Pharmacotherapy(2018)
摘要
•The blood glucose in STZ plus HFD-induced diabetic rats could be partially reversed by berberine.•Berberine was significantly associated with improvement in the trabecular bone mass loss and amelioration of the microarchitecture deterioration in diabetic rats.•Berberine has a protective effect on bone histomorphometry.•Oxidation, one of the important contributors for diabetic osteopathy, also was controlled by berberine.
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关键词
ROS,PTP1B,AMPK,gluT1,RANKL,NF-kB,BMSCs,MAPK,SAMP6,MDA,SOD,P-TEFb,STZ,HFD,PGLs,BV/TV,TbN,TbTh,TbSp,SMI,EDTA,ALP,TRAP,PTH,8-OHdG,ELISA,GST
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