Possible therapeutic potential of berberine in the treatment of STZ plus HFD-induced diabetic osteoporosis.

•The blood glucose in STZ plus HFD-induced diabetic rats could be partially reversed by berberine.•Berberine was significantly associated with improvement in the trabecular bone mass loss and amelioration of the microarchitecture deterioration in diabetic rats.•Berberine has a protective effect on bone histomorphometry.•Oxidation, one of the important contributors for diabetic osteopathy, also was controlled by berberine.