Design, display and immunogenicity of HIV1 gp120 fragment immunogens on virus-like particles.

Mansi Purwar,Jonathan K Pokorski,Pranveer Singh,Sanchari Bhattacharyya,Heather Arendt,Joanne DeStefano, Celia C La Branche,David C Montefiori,M G Finn,Raghavan Varadarajan

Vaccine（2018）

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摘要

•gp120 fragments with enhanced stability, affinity to CD4bs antibody b12 were designed.•Stabilized fragments were displayed on Qβ VLP’s and used in rabbit immunizations.•The most stable fragment elicited cross clade Tier 1 and weak Tier 2 neutralization.•Priming with the fragments resulted in an epitope focused response to the CD4bs.

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关键词

Protein stability,Immune focusing,Neutralizing antibodies,Vaccine,Nanoparticles

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