Developmental regulation of type 1 and type 3 IFN production and risk for infant infections and asthma development.

Patrick G Holt,Danny Mok,Debasis Panda,Lynnsey Renn,Giulia Fabozzi, Nick H deKlerk,Merci M H Kusel,Michael Serralha,Elysia M Hollams,Barbara J Holt,Peter D Sly,Ronald L Rabin

Journal of Allergy and Clinical Immunology（2019）

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摘要

T1/3IFN response capacity appears strongly developmentally constrained at birth. Infants in whom this negative regulation is strongest manifest increased risk for severe respiratory infections during infancy and subsequent persistent wheeze.

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关键词

Type 1 and type 3 interferons,persistent wheeze,asthma development,infant respiratory tract infections,febrile lower respiratory tract infections,hygiene hypothesis,innate immune development

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