Correlation between CD4 + CD28 null T lymphocytes, regulatory T cells and plaque rupture: An Optical Coherence Tomography study in Acute Coronary Syndromes.

•Plaque rupture at OCT evaluation is associated to a specific adaptive immune system signature.•A deeper perturbation of adaptive immunity might be involved in fibrous cap thinning.•Molecular and morphological plaque phenotyping might be a new frontier for personalized medicine.