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Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS

Timothy R. Hodges,Jason R. Abbott,Andrew J. Little,Dhruba Sarkar,James M. Salovich,Jennifer E. Howes,Denis T. Akan,Jiqing Sai,Allison L. Arnold,Carrie Browning,Michael C. Burns,Tammy Sobolik,Qi Sun,Yugandhar Beesetty,Jesse A. Coker,Dirk Scharn,Heinz Stadtmueller,Olivia W. Rossanese,Jason Phan,Alex G. Waterson,Darryl B. McConnell,Stephen W. Fesik

JOURNAL OF MEDICINAL CHEMISTRY（2018）

Cited 42|Views44
Key words
Receptor Activation
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