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Structural analysis reveals the formation and role of RNA G-quadruplex structures in human mature microRNAs.

Ka Lung Chan,Boya Peng,Mubarak I Umar,Chun-Yin Chan,Aleksandr B Sahakyan,Minh T N Le,Chun Kit Kwok

CHEMICAL COMMUNICATIONS（2018）

Cited 39|Views22
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Abstract
Here we identify hundreds of RNA G-quadruplex (rG4) candidates in microRNAs (miRNAs), characterize the miRNA structure and miRNA-mRNA interactions on several mammalian-conserved miRNAs, and reveal the formation of rG4s in miRNAs. Notably, we study the effect of these rG4s in cells and uncover the role of rG4s in miRNA-mediated post-transcriptional regulation.
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g-quadruplex
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