Synthesis and biological evaluation of novel 5,6-dihydropyrimido[4,5-f]quinazoline derivatives as potent CDK2 inhibitors.
Bioorganic & Medicinal Chemistry Letters（2018）
Abstract
•New 5,6-dihydropyrimido[4,5-f]quinazoline derivatives were designed and synthesized.•CDK2 inhibitory activity was evaluated.•Anti-proliferative activity was in vitro evaluated against MCF-7 and HCT116 cells.•Molecular docking in the active site of CDK2 enzyme.
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Key words
Cyclin dependent kinase,Anticancer,Design and discovery,Molecular docking
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