Copper-Catalyzed [2 + 3] Cyclization of α-Hydroxyl Ketones and Arylacetonitriles: Access to Multisubstituted Butenolides and Oxazoles.
JOURNAL OF ORGANIC CHEMISTRY(2018)
摘要
A copper-catalyzed [2 + 3] formal cyclization reaction between alpha-hydroxyl ketones and arylacetonitriles has been developed. The reaction outcome was ultimately dependent on the structure of the alpha-hydroxy ketones employed. Tertiary alpha-hydroxy ketones gave 3,4,5,5-tetrasubstituted butenolides as the sole products, while secondary alpha-hydroxy ketones furnished 2,4,5-trisubstituted oxazoles selectively. This method has many advantages, such as the use of easily available substrates, broad substrate scope, good functional tolerance, and milder reaction conditions.
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关键词
Metal-Catalyzed Reactions,Transition Metal Catalysis
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