Synthesis, antimalarial activities and cytotoxicities of amino-artemisinin-1,2-disubstituted ferrocene hybrids.

Christo de Lange,Dina Coertzen,Frans J Smit,Johannes F Wentzel,Ho Ning Wong,Lyn-Marie Birkholtz,Richard K Haynes,David D N'Da

Bioorganic & Medicinal Chemistry Letters（2018）

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摘要

•Successful synthesis of amino-artemisinin-1,2-disubstituted ferrocene hybrids.•Hybrids more active against Pf resistant parasites than clinical artemisinins.•High gametocytes transmission blocking achieved at 100 nM with morpholino hybrid.

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关键词

Amino-artemisinin,Ferrocene,Hybrid drug,Malaria,Cytotoxicity

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