Ultrahigh-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) assay for simultaneous quantifications of CZ48, lactone-stabilized camptothecin, and camptothecin and their pharmacokinetic and biliary evaluations in rats.
Journal of Pharmaceutical and Biomedical Analysis（2018）
Abstract
•Developed and validated a UHPLC–MS/MS assay to simultaneously quantify CZ48 and CPT•Solid phase extraction was used to reduce matrix effects of bile on CZ48 and CPT•The method was applied to quantify CZ48 and CPT concentrations in plasma and bile•Biliary excretions of CZ48 and CPT were evaluated after an intravenous dose of CZ48
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Key words
CZ48,Camptothecin,UHPLC–MS/MS,Solid phase extraction (SPE),Pharmacokinetics (PK),Biliary excretion
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