Shortened Activated Partial Thromboplastin Time and Increased Superoxide Dismutase Levels Are Associated with Type 2 Diabetes Mellitus.

Background To determine differences in levels of coagulation and superoxide dismutase in normal controls and type 2 diabetes mellitus patients with different stages of glucose control. Methods. Type 2 diabetes mellitus patients were divided into two groups according to their fasting blood glucose (GM1 and GM2) and HbAl c levels (BM1 and BM2). Blood clotting times and levels of serum superoxide dismutase were compared among the three groups. A receiver operating characteristic (ROC) curve was generated to evaluate predictors and determine their sensitivities and specificities. A Pearson correlation analysis was performed on the type 2 diabetes mellitus patients using standard methods to evaluate the association of serum levels of superoxide dismutase and coagulation parameters with certain disease risk factors. A multiple linear stepwise regression analysis was also performed. Results. There is a significant difference in levels of superoxide dismutase (SOD) and activated partial thromboplastin time (APTT) between normal controls and type 2 diabetes patients with varying glucose tolerance statuses (P<0.001). The difference between GM1 and GM2 with respect to APTT was also statistically significant (P=0.048). The area under the ROC for APTT and SOD was 0.705 and 0.707, respectively. An inverse and highly significant correlation was found between APTT and fasting plasma glucose (r =-0.177, P=0.024), and the serum level of SOD was negatively correlated with age (r=-0.309, P<0.001), D-Dimer (r=-0.253, P=0.001) and APTT (r=-0.2, P=0.007). Conclusions. Shorter APTT and increased SOD levels might be useful hemostatic markers in patients with type 2 diabetes mellitus.