Rapid high-resolution T 1 mapping using a highly accelerated radial steady-state free-precession technique.

Background T-1 mapping is often used in some clinical protocols. Existing techniques are limited in slice coverage, and/or spatial-temporal resolution, or require long acquisitions. Here we present a multi-slice inversion-recovery (IR) radial steady-state free precession (radSSFP) pulse sequence combined with a principal component (PC) based reconstruction that overcomes these limitations. Purpose To develop a fast technique for multi-slice high-resolution T-1 mapping. Study Type Technical efficacy study done prospectively. Phantom/Subjects IR-radSSFP was tested in phantoms, five healthy volunteers, and four patients with abdominal lesions. Field Strength/Sequence IR-radSSFP was implemented at 3T. Assessment Computer simulations were performed to optimize the flip angle for T-1 estimation; testing was done in phantoms using as reference an IR spin-echo pulse sequence. T-1 mapping with IR-radSSFP was also assessed in vivo (brain and abdomen) and T-1 values were compared with literature. T-1 maps were also compared with a radial IR-FLASH technique. Statistical Tests A two-tailed t-test was used to compare T-1 values in phantoms. A repeatability study was carried out in vivo using Bland-Altman analysis. Results Simulations and phantom experiments showed that a flip angle of 20 was optimal for T-1 mapping. When comparing single to multi-slice experiments in phantoms there were no significant differences between the means T-1 values (P = 0.0475). In vivo results show that T-1 maps with spatial resolution as high as 0.69 mm x 0.69 mm x 2.00 mm (brain) and 0.83 mm x 0.83 mm x 3.00 mm (abdomen) can be generated for 84 brain slices in 3 min and 10 abdominal slices in a breath-hold; T-1 values were comparable to those reported in literature. The coefficients of variation from the repeatability study were 1.7% for brain and 2.5-2.7% in the abdomen. Data Conclusion A multi-slice IR-radSSFP technique combined with a PC-based reconstruction was demonstrated for higher resolution T-1 mapping. This technique is fast, motion-insensitive and yields repeatable T-1 values comparable to those in literature. Level of Evidence: 2 Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 2019;49:239-252.