Sinomenine protects against E.coli-induced acute lung injury in mice through Nrf2-NF-κB pathway.

•E.coli induced histological changes and increased W/D ratio and MPO activity, indicating tissues damage.•E.coli induced inflammation and oxidative stress by increasing the expression of inflammatory cytokines and MDA content.•Sinomenine has a protective effect against E.coli induced acute lung injury (ALI).•SIN ameliorates E.coli-induced lung injury through activation Nrf2-Keap1 and inhibition NF-κB pathways.