The role of HLA-A ∗33:01 in Patients with Cholestatic Hepatitis attributed to Terbinafine.

•Patients with terbinafine hepatotoxicity most often present with a mixed/cholestatic liver injury profile.•Caucasian patients were more likely to be carriers of HLA-A*33:01, B*14:02, C*08:02 than controls (91% vs. 1.6%)•A similar HLA haplotype of HLA-A*33:03 was also over-represented in Asian American terbinafine hepatotoxicity cases.•Molecular docking studies suggest that terbinafine may interact with these HLA alleles.