Intrathecal K free light chain synthesis in multiple sclerosis at clinical onset associates with local IgG production and improves the diagnostic value of cerebrospinal fluid examination
Multiple Sclerosis and Related Disorders(2018)
摘要
•Immunoglobulin free light chains (FLC) are intrathecally synthesized in MS.•A correlation between intrathecal IgG synthesis and κFLC, but not λFLC, was found.•Intrathecal IgM synthesis mildly associated with λFLC, but not with κFLC.•At clinical onset, 26% of MS patients without IgGOB had increased FLC Indexes.
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关键词
Multiple sclerosis,Kappa free light chains,Lambda free light chains,Intrathecal IgG synthesis
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