AML-associated mutation of nucleophosmin compromises its interaction with nucleolin.

Markéta Šašinková,Aleš Holoubek,Petra Otevřelová,Kateřina Kuželová,Barbora Brodská

The International Journal of Biochemistry & Cell Biology（2018）

引用 15|浏览24

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摘要

•Leukemia-related mutation of nucleophosmin disrupts its interaction with nucleolin.•Stability of nucleophosmin oligomers is attenuated by C-terminal mutation.•All-trans retinoic acid stabilizes nucleophosmin oligomers.•Nucleolin/nucleophosmin ratio is enhanced in patients with nucleophosmin mutation.

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关键词

Nucleophosmin,AML,Mutation,Nucleolin,Interaction,Oligomerization

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