Petri net siphon analysis and graph theoretic measures for identifying combination therapies in cancer.

Epidermal Growth Factor Receptor (EGFR) signaling to the Ras-MAPK pathway is implicated in the development and progression of cancer and is a major focus of targeted combination therapies. Physiochemical models have been used for identifying and testing the signal-inhibiting potential of targeted therapies; however, their application to larger multi-pathway networks is limited by the availability ...