Design, synthesis and antibacterial properties of pyrimido[4,5-b]indol-8-amine inhibitors of DNA gyrase.

David H McGarry,Ian R Cooper,Rolf Walker, Catherine E Warrilow,Mark Pichowicz,Andrew J Ratcliffe,Anne-Marie Salisbury,Victoria J Savage,Emmanuel Moyo,John Maclean,Andrew Smith,Cédric Charrier,Neil R Stokes,David M Lindsay,William J Kerr

Bioorganic & Medicinal Chemistry Letters（2018）

引用 14|浏览21

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摘要

•Discovery of amide-linked pyrimido[4,5-b]indol-8-amine inhibitors of DNA gyrase.•Potent against gram-positive bacteria (MIC < 1 µg/mL).•Excellent activity against drug-resistant strains of Mycobacterium tuberculosis.

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关键词

ESKAPE pathogens,Anti-infectives,Topoisomerases,DNA gyrase,Pyrimido[4,5-b]indol-8-amine

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