Asymmetric Synthesis of a Potent CXCR7 Modulator Featuring a Hindered Tertiary β‑Amino Amide Stereocenter
Organic Letters(2018)
摘要
A practical and asymmetric synthesis of a small-molecule CXCR7 modulator featuring a highly functionalized and hindered tertiary β-amino amide framework is reported. The cornerstone of this strategy relied on the intermediacy of a reactive aziridinium species, which, following regioselective ring opening with cyanide, furnished the desired chiral β-tertiary amino nitrile for further elaboration. As a means of further highlighting this synthetic strategy, an expanded scope of hindered β-amino amide synthesis is also presented.
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关键词
potent cxcr7 modulator,synthesis
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