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2,4-Diamino-6-methylpyrimidines for the potential treatment of Chagas' disease.

Michael G Thomas,Manu De Rycker, Ignacio Cotillo Torrejon,John Thomas,Jennifer Riley,Daniel Spinks,Kevin D Read,Tim J Miles,Ian H Gilbert,Paul G Wyatt

Bioorganic & Medicinal Chemistry Letters（2018）

Cited 5|Views39
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Abstract
•Optimising selectivity and metabolic stability of anti-Chagas’ disease pyrimidines.•Structure activity relationships development to optimise developability properties.•Development of compound not targeting T. cruzi C14 α-demethylase.
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Key words
Trypanosoma cruzi,Chagas’ disease,SAR studies
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