Modulation of P2X7 purinergic receptor activity by extracellular Zn 2+ in cultured mouse hippocampal astroglia.

Gergely Kovács,Zsuzsanna Környei,Krisztina Tóth,Mária Baranyi,János Brunner,Máté Neubrandt,Ádám Dénes,Beáta Sperlágh

Cell Calcium（2018）

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摘要

•P2X7 receptor (P2X7R) was expressed in both neurons and glial cells in primary mouse hippocampal neuron-glial culture.•Propidium iodide uptake via P2X7Rs was inhibited by extracellular Zn2+ in both cell types.•Extracellular free zinc ions decreased P2X7R-mediated calcium influx in glial cells.

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关键词

CNS,MDD,BzATP,BBG,OGB-1,PI,VGluT1

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