Non-invasive PET imaging of brain inflammation at disease onset predicts spontaneous recurrent seizures and reflects comorbidities

Daniele Bertoglio,Jeroen Verhaeghe,Eva Santermans,Halima Amhaoul,Elisabeth Jonckers,Leonie Wyffels,Annemie Van Der Linden,Niel Hens,Steven Staelens,Stefanie Dedeurwaerdere

Brain, Behavior, and Immunity（2017）

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摘要

•KASE rats display depression-like and sensorimotor-related comorbidities.•Translocator protein PET imaging correlates severity of investigated comorbidities.•Translocator protein PET imaging predicts spontaneous seizure frequency.•Non-invasive PET imaging is a prognostic biomarker for seizure frequency.

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关键词

SRS,TSPO,PET,SE,KA,KASE,PED,vEEG,SUV,PCA,PLS,VOI,WNT,SPT,FST,SO2

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