Ene Reaction Of Nitrosocarbonyl Mesitylene With The Cinnamyl Alcohol: Metabolic Activity And Apoptosis Of The Synthetized 6-Chloropurine N,O-Nucleoside Analogues

Nitrosocarbonyl mesitylene intermediate undergoes an ene reaction with cinnamyl alcohol affording the corresponding 5-hydroxy-isoxazolidine in fair yields. The synthesized 5-acetoxy-isoxazolidine serves as synthon for the preparation of 6-chloropurine N,O-nucleoside analogues, according to the Vorbruggen reaction. The compounds were evaluated for their metabolic and apoptotic activity, and their structure-activity relationship is discussed.