Enantioselective Total Synthesis of (−)-Misramine
Organic Letters(2018)
摘要
The enantioselective total synthesis of an unusual pentacyclic proaporphine alkaloid, (−)-misramine, was achieved. The synthetic strategy relied on an enantioselective intramolecular Friedel–Crafts-type 1,4-addition using an asymmetric organocatalyst to construct a spiroindane skeleton containing an all-carbon quaternary stereocenter and a double reductive amination of the keto-aldehyde to form a piperidine ring toward the end of the synthesis. This work is the first example of asymmetric synthesis of a proaporphine alkaloid.
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关键词
enantioselective total synthesis,total synthesis
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