Experimental assessment of a myocyte-based multiscale model of cardiac contractile dysfunction.

•A multiscale model of the cardiovascular system was built based on a human myocyte model.•The effects of halothane, an anesthetic that at high doses elicits acute cardiac dysfunction, were simulated in the myocyte and analyzed at the myocyte, ventricular and circulatory levels.•The multiscale model effectively reproduced contractile and hemodynamic dysfunction in sheep induced by an overdose of halothane.