Short term comparison between blind and ultrasound guided injection in morton neuroma

Objective The aim of this work is to compare the effectiveness of blind and ultrasound-guided injection for Morton’s neuroma (MN) to determine which is more appropriate as the initial procedure in conservative treatment. Methods This is an evaluator-blinded randomised trial. Of the 56 included patients, 27 were assigned to the blind group (A) and 29 to the ultrasound-guided group (B). Injection includes 1 ml of 2% mepivacaine and 40 mg of triamcinolone in each web space with MN. The included patients were assessed clinically by VAS score and the Manchester Foot Pain and Disability Score (MFPDS). The follow-up was performed at 15 days, 1 month, 45 days, 2 months, 3 months and 6 months after the initial injection. Results No differences in age or clinical measurements were found at presentation between group A and group B. At the follow-up, the ultrasound-guided group showed greater symptomatic relief at several stages of the follow-up: 45 days (VAS 3.0 ± 0.5 versus 5.5 ± 0.5, p = 0.001; MFPDS: 32.2 ± 1.8 versus 38.8 ± 2.0, p = 0.018), 2 months (VAS: 3.1 ± 0.5 versus 5.6 ± 0.5, p = 0.002; MFPDS: 31.5 ± 1.9 versus 38.5 ± 2.1, p = 0.020) and 3 months (VAS: 3.1 ± 0.4 versus 5.2 ± 0.6, p = 0.010; MFPDS: 31.2 ± 1.9 versus 37.7 ± 2.4, p = 0.047). Conclusion Injection of MN under ultrasound guidance provides a statistically significant improvement at some stages of the follow-up (45 days, 2 and 3 months), compared with blind injection. Key Points • Ultrasound-guided steroid injections in Morton’s neuroma provide short-term pain relief to over 60% of the patients. • Ultrasound-guided injections in Morton’s neuroma lead to a higher percentage of short-term pain relief than blind injections. • Ultrasound-guided injections in Morton’s neuroma lead to a lower percentage of skin side effects than blind injections.