Nitrosative Stress as a Modulator of Inflammatory Change in a Model of Takotsubo Syndrome.

Sven Y Surikow,Thanh H Nguyen,Irene Stafford,Matthew Chapman, Sujith Chacko,Kuljit Singh,Giovanni Licari,Betty Raman,Darren J Kelly,Yuan Zhang,Mark T Waddingham,Doan T Ngo, Alexander P Bate, Su Jen Chua,Michael P Frenneaux,John D Horowitz

JACC: Basic to Translational Science（2018）

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摘要

•Treatment of female rats with a single dose of isoproterenol results in apical hypokinesis mimicking Takotsubo syndrome•Myocardial inflammation includes increased content of 3-nitrotyrosine and poly(ADP-ribose), indicating nitrosative stress and PARP-1 activation, respectively•Pretreatment with 3-aminobenzamide (a PARP-1 inhibitor) attenuates negative inotropic changes•We conclude that the peroxynitrite/PARP-1 cascade contributed to negative inotropy in this model of Takotsubo syndrome, consistent with the limited data available in patients

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关键词

myocardial inflammation,oxidative stress,poly(ADP-ribose) polymerase-1,Takotsubo cardiomyopathy

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