Expression of Corticosteroid Regulated Genes By Peripheral Blood Mononuclear Cells in Children with Asthma.

Elena Goleva,Denise C Babineau,Michelle A Gill,Leisa P Jackson,Baomei Shao,Zheng Hu,Andrew H Liu,Cynthia M Visness,Christine A Sorkness,Donald Y M Leung,Alkis Togias,William W Busse

Journal of Allergy and Clinical Immunology（2019）

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摘要

PBMC of children with difficult-to-control asthma treated with guidelines-based therapy and requiring high dose inhaled corticosteroids had reduced in vitro responsiveness to corticosteroids.

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关键词

Asthma,steroid resistance,corticosteroids,glucocorticoid receptor

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