Melamine causes testicular toxicity by destroying blood-testis barrier in piglets.

Lingling Chang,Zheng Lu,Delong Li,Liang Zhang,Zhenyu Wang,Qian Du,Yong Huang,Xiaomin Zhao,Dewen Tong

Toxicology Letters（2018）

引用 19|浏览10

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摘要

•Melamine (MA) caused male reproductive toxicity in weaned piglets.•MA disrupted blood-testis barrier (BTB) ultrastructure and integrity in testis.•MA induced down-regulation of BTB junction proteins (occludin, ZO-1, N-cadherin, Connexin-43) in testis•MA induced up-regulation of MAPK pathway regulatory proteins (p-Erk, p-JNK and p-p38)in testis.

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关键词

Melamine,Testicular toxicity,Blood-testis barrier,BTB junction proteins,Piglets

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