Heme Oxygenase-1 protects astroglia against manganese-induced oxidative injury by regulating mitochondrial quality control.

Roxana Mayra Gorojod,Agustina Alaimo,Soledad Porte Alcon,Jimena Hebe Martinez, María Eugenia Cortina,Elba Susana Vazquez,Mónica Lidia Kotler

Toxicology Letters（2018）

引用 18|浏览12

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摘要

•Manganese (Mn) exposure induces HO-1 upregulation in rat astrocytoma C6 cells.•HO-1 decreases both intracellular and mitochondrial reactive oxygen species.•Hemin-induced HO-1 ameliorates Mn- induced mitochondrial damage.•HO-1 maintains both mitochondrial fusion/fission and biogenesis/mitophagy balances.

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关键词

Heme Oxygenase-1,Mitochondrial quality control,Oxidative stress,Astroglia,Manganese,Manganism

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