Metabolic reprogramming in colon cancer reversed by DHTS through regulating PTEN/AKT/HIF1α mediated signal pathway.

Lin Wang,Ziru Yu,Shuyue Ren,Junke Song,Jinhua Wang,Guanhua Du

Biochimica et Biophysica Acta (BBA) - General Subjects（2018）

引用 12|浏览6

暂无评分

摘要

•DHTS reduced glycolysis, mitochondrial OXPHOS and FFA content in HCT116 cells.•DHTS decreased the efficiency of glucose and FA as mitochondrial fuels.•DHTS suppressed the flexibility of other mitochondrial fuels in deficiency of glucose.•DHTS reversed metabolic reprogramming via SITR3/PTEN/AKT/HIF1α signaling pathway.

查看译文

关键词

DHTS,LCFAs,PTEN,HIF1α,HKII,p-AKT,RHEB,SIRT3,p-mTOR,PDK4,PHD,PDH2,FFA,FA

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要