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Discovery of MK-8318, a Potent and Selective CRTh2 Receptor Antagonist for the Treatment of Asthma.

Xianhai Huang,Jason Brubaker,Wei Zhou,Purakkattle J. Biju,Li Xiao,Ning Shao,Ying Huang,Li Dong,Zhidan Liu,Rema Bitar,Alexei Buevich,Joon Jung,Scott L. Peterson,John W. Butcher,Joshua Close,Michelle Martinez,Rachel N. MacCoss,Hongjun Zhang, Scott Crawford,Kevin D. McCormick,Robert Aslanian,Ravi Nargund,Craig Correll,Francois Gervais,Hongchen Qiu,Xiaoxin Yang,Charles Garlisi,Diane Rindgen,Kevin M. Maloney,Phieng Siliphaivanh,Anandan Palani

ACS Medicinal Chemistry Letters（2018）

Cited 9|Views29
Key words
MK-8318,CRTh2 receptor,DP2 receptor,receptor antagonist,homology model,PK lead optimization,pharmacokinetics,asthma,tetrahydroquinoline
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