The Cf3-Dast-Induced Deacylative Trifluoromethylthiolation Of Cyclic 1,3-Diketones/Lactams/Lactones And Its Extension To Deacylative Pentafluorophenylthiolation

A trifluoromethyl analogue of diethylaminosulfur trifluoride (CF3-DAST)induced deacylative trifluoromethylthiolation of cyclic 1,3-diketones, lactams, and lactones that provides cyclic alpha-trifluoromethylthioketones, lactams, and lactones is reported. To the best of our knowledge, this method represents the first example of the trifluoromethylthiolation of lactams. A corresponding deacylative pentafluorophenylthiolation using a pentafluorophenyl analogue of diethylaminosulfur trifluoride (C6F5-DAST) was also attempted.