SNX17 produces anti-arrhythmic effects by preserving functional SERCA2a protein in myocardial infarction.

•SNX17, a member of SNXs family, has been established playing a fundamental role in endosomes recycling and lysosomal degradation relevance to diversity of human diseases.•Our findings unexpectedly reveal that a unique aspect of the SNX17-dependent management is the judgement of cardiomyocyte fate.•The deficiency of SNX17 initiates SERCR2a protein downregulation by disturbing intracellular proper transport of SERCA2a.•A plausible underlying mechanism arouse in this study is supplement of SNX17 stabilize the intracellular calcium disorders by recovering the SERCA2a protein level in setting of myocardial infarction.•Considering that SNX17 is the guarantee of SERCA2a performance, aiming directly at SNX17 might offer a safe and efficient intervention and therapeutic strategy for SERCA2a-associated cardiovascular diseases.