Increased Doses Lead To Higher Drug Exposures Of Levofloxacin For Treatment Of Tuberculosis

Patients with multidrug-resistant tuberculosis in Peru and South Africa were randomized to a weight-banded nominal dose of 11, 14, 17, or 20 mg/kg/day levofloxacin (minimum, 750 mg) in combination with other second-line agents. A total of 101 patients were included in noncompartmental pharma-cokinetic analyses. Respective median areas under the concentration-time curve from 0 to 24 h (AUC(0-24)) were 109.49, 97.86, 145.33, and 207.04 mu g . h/ml. Median maximum plasma concentration (C-max) were 11.90, 12.02, 14.86, and 19.17 mu g/ml, respectively. Higher levofloxacin doses, up to 1,500 mg daily, resulted in higher exposures. (This study has been registered at ClinicalTrials.gov under identifier NCT01918397.)