Cryo-Em Structure Of The Polycystin 2-L1 Ion Channel
ELIFE(2018)
摘要
We report the near atomic resolution (3.3 angstrom) of the human polycystic kidney disease 2-like 1 (polycystin 2-l1) ion channel. Encoded by PKD2L1, polycystin 2-l1 is a calcium and monovalent cation-permeant ion channel in primary cilia and plasma membranes. The related primary cilium-specific polycystin-2 protein, encoded by PKD2, shares a high degree of sequence similarity, yet has distinct permeability characteristics. Here we show that these differences are reflected in the architecture of polycystin 2-l1.
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关键词
PC-2L1,TRP channel,calcium,cryo-EM,human,molecular biophysics,primary cilia,structural biology
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